function
protein secretion
product
signal peptidase I
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
1,511,308 → 1,511,889
Phenotypes of a mutant
a ''[gene|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|sipS] [gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]'' double mutant is not viable [Pubmed|9694797]The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)Protein family
peptidase S26 family (according to Swiss-Prot)Paralogous protein(s)
[protein|CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0|SipS], [protein|9824F9CF9C2028AF267AC43FE7FD8590E8231AB8|SipU], [protein|ADEEA5E15C100C1DC6E129B9A3E6DECAFCA8C409|SipV] Structure
[PDB|4NV4] (from B. anthracis, 44% identity)[SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]
description
[Pubmed|9694797]
regulatory mechanism
[protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]: activation, [Pubmed|9694797], in [regulon|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU regulon]view in new tabBiological materials
Mutant
BKE14410 (Δ[gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC, downstream forward: _UP4_TAAAAACGCCTTGCTGGCCTBKK14410 (Δ[gene|C2EAE417DB9250B88BB0E25D4AE760BDE82EFD86|sipT]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14410 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC, downstream forward: _UP4_TAAAAACGCCTTGCTGGCCTLabs working on this gene/protein
[SW|Jan Maarten van Dijl], Groningen, NetherlandsReferences
Reviews
Original publications
11807061,9325333,9694797,28088521,29358498